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Thermodynamic and Kinetic Approaches for Drug Discovery to Target Protein Misfolding and Aggregation

Michele Vendruscolo
Publisher Taylor & Francis
Language English
Published Jun 05, 2023
Edition Review Article

A review of drug-discovery strategies for protein-misfolding diseases that compares thermodynamic stabilization of native protein states with kinetic approaches that slow aggregation. It discusses current disease mechanisms, therapeutic targets, and prospects for treatments addressing protein misfolding and amyloid formation.

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